Dissolution Stability Study of Cefadroxil Extemporaneous Suspensions

Dissolution Stability Study of Cefadroxil Extemporaneous Suspensions

Dissolution studies have become matter of great significance because, in most cases, drug dissolution is the rate-limiting step in the absorption process. As occurs with solid oral dosage forms, heterogeneous disperse systems (suspensions) could also have some problems with their in vitro dissolution. The dissolution behavior of four different brands of cefadroxil extemporaneous suspensions ava...

Extemporaneous Isoniazid Mixture: Stability Implications

Stability of extemporaneous enalapril maleate suspensions for pediatric use prepared from commercially available tablets.

In this paper, the stability of enalapril maleate in oral formulations prepared from commercially available tablets was investigated. Extemporaneously compounded, 0.1 mg/mL and 1.0 mg/mL, oral suspensions of enalapril maleate in sugar-containing and sugar-free vehicles were stored in the absence of light at 4 degrees and 25 degrees C for 30 days. Enalapril maleate stability was quantified after...

Stability of an alternative extemporaneous captopril fast-dispersing tablet formulation versus an extemporaneous oral liquid formulation.

BACKGROUND Administration of medications to pediatric patients is challenging because many drugs are not commercially available in appropriate dosage formulations and/or strengths. Consequently, these drugs are prepared extemporaneously as oral liquid (OL) formulations using marketed tablets or capsules. In many cases, the stability of these extemporaneous preparations, which may affect their t...

Stability of active suspensions.

We study theoretically the stability of "active suspensions," modeled here as a Stokesian fluid in which are suspended motile particles. The basis of our study is a kinetic model recently posed by Saintillan and Shelley [D. Saintillan and M. J. Shelley, Phys. Rev. Lett. 100, 178103 (2008); D. Saintillan and M. J. Shelley, Phys. Fluids 20, 123304 (2008)] where the motile particles are either "pu...